Study of Some Hematological, Biochemical, and Antioxidant markers in Colon Cancer Patients in Erbil Governorate
Hematological, Biochemical, and Antioxidant markers in Colon Cancer
DOI:
https://doi.org/10.63841/iue32639Keywords:
colon cancer, oxidative stress, CA 19-9, testosterone, thyroid-stimulating hormone.Abstract
Colon cancer is a major contributor to cancer-related morbidity and mortality worldwide, with an increasing incidence in the Kurdistan Region of Iraq. The research evaluated hematological, biochemical, oxidative stress, hormonal, and tumor marker profiles in male colon cancer patients from the Erbil governorate. A total of 100 volunteers were selected for this study, comprising 70 male patients and 30 healthy male controls. Hematological data revealed significant reductions in patients' red blood cell count, hemoglobin concentration, and white blood cell count, suggesting anemia and immunosuppression. Liver function tests revealed elevated SGPT levels, indicating possible hepatic involvement, whereas renal function markers remained within normal limits. The enzyme-linked immunosorbent assay (ELISA) evaluated oxidative stress indicators, including malondialdehyde (MDA), superoxide dismutase, and glutathione peroxidase. The results demonstrated reduced activity of GPx and SOD, indicating a compromised enzymatic antioxidant defense. Furthermore, elevated levels of MDA were noted, signifying increased lipid peroxidation and antioxidant response. Hormonal analysis revealed decreased free testosterone and increased thyroid-stimulating hormone (TSH) levels in individuals; however, these changes were not statistically significant. The tumor marker carbohydrate antigen 19-9 (CA 19-9) was significantly elevated in patients, confirming its effectiveness in identifying and monitoring colon cancer. Male colon cancer patients exhibited significant hematological alterations, elevated liver enzymes (SGPT), oxidative stress dysregulation, and increased CA 19-9 levels. Hormonal changes were seen but did not reach statistical significance. These results may aid in the detection and clinical management of colorectal cancer.
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